How nucleotide excision repair protects against cancer

Nat Rev Cancer. 2001 Oct;1(1):22-33. doi: 10.1038/35094000.


Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type--nucleotide excision repair (NER)--specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Damage
  • DNA Repair* / genetics
  • Disease Models, Animal
  • Humans
  • Mutation
  • Neoplasms / etiology
  • Neoplasms / genetics
  • Neoplasms / prevention & control*
  • Transcription, Genetic
  • Xeroderma Pigmentosum / etiology
  • Xeroderma Pigmentosum / genetics