Putting Tumours in Context

Nat Rev Cancer. 2001 Oct;1(1):46-54. doi: 10.1038/35094059.

Abstract

The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Matrix Metalloproteinases / physiology
  • Neoplasms / etiology*
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Stromal Cells / physiology
  • Wound Healing

Substances

  • Matrix Metalloproteinases