The linkage information content value of polymorphism genetic markers in model-free linkage analysis

Hum Hered. 2002;53(1):45-8. doi: 10.1159/000048604.

Abstract

Guo and Elston [Hum Hered 1999;49:112-118] developed a linkage information content (LIC) value to measure the informativeness of a marker for identity-by-descent (IBD) sharing status of relative pairs. LIC values were derived for five types of relative pairs: full sib, half sib, grandparent-grandchild, first cousin and avuncular. In this paper, we give corrected LIC values for full sib, grandparent-grandchild, first cousin and avuncular pairs, and indicate the availability of a computer program to calculate them.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping / methods*
  • Data Interpretation, Statistical
  • Genetic Linkage
  • Genetic Markers*
  • Humans
  • Polymorphism, Genetic*

Substances

  • Genetic Markers