Early results of 2 surgeons involved in a prospective study of the Universal total wrist prosthesis (KMI, San Diego, CA) are reported. Twenty-two prostheses were implanted in 19 patients for the treatment of severe rheumatoid arthritis. Two-year follow-up results of 8 wrists and 1-year follow-up results of 14 wrists were reviewed. Total arcs of motion (flexion-extension, radial-ulnar deviation, and pronation-supination) all improved significantly after arthroplasty. Individual motions that were most limited before surgery (extension, radial deviation, and supination) improved the most. Disabilities of the Arm, Shoulder, and Hand outcome scores improved 14 points at 1 year and 24 points at 2 years. Three prostheses (14%) were unstable and required further treatment; all 3 were in patients with highly active disease and severe wrist laxity. The Universal prosthesis provides a good early outcome in rheumatoid patients without severe preoperative wrist laxity.