Chromosome translocations: dangerous liaisons revisited

Nat Rev Cancer. 2001 Dec;1(3):245-50. doi: 10.1038/35106108.


Although it has been clear for more than a century that the chromosomes in human tumour cells are often wildly abnormal, there has been controversy as to whether these changes are primary events or are merely secondary epiphenomena that reflect the genomic instability of these cells. The prevailing view for most of this period was that chromosome changes were secondary events. What happened to change this view?

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Transformation, Neoplastic / genetics
  • Cytogenetics / history
  • Forecasting
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / history
  • Neoplasms / genetics*
  • Philadelphia Chromosome
  • Translocation, Genetic*