Helicobacter pylori and gastrointestinal tract adenocarcinomas

Nat Rev Cancer. 2002 Jan;2(1):28-37. doi: 10.1038/nrc703.

Abstract

Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / etiology*
  • Adenocarcinoma / microbiology
  • Adenocarcinoma / prevention & control
  • Adolescent
  • Adult
  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Apoptosis
  • Atrophy
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Child
  • Child, Preschool
  • Cytokines / genetics
  • Disease Progression
  • Esophageal Neoplasms / epidemiology
  • Esophageal Neoplasms / prevention & control
  • Female
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Gastritis / microbiology
  • Gastroesophageal Reflux / epidemiology
  • Gastrointestinal Neoplasms / epidemiology
  • Gastrointestinal Neoplasms / etiology*
  • Gastrointestinal Neoplasms / microbiology
  • Gastrointestinal Neoplasms / prevention & control
  • Genetic Predisposition to Disease
  • Gerbillinae
  • Helicobacter Infections / complications*
  • Helicobacter Infections / drug therapy
  • Helicobacter Infections / epidemiology
  • Helicobacter pylori / isolation & purification
  • Helicobacter pylori / pathogenicity*
  • Helicobacter pylori / physiology
  • Humans
  • Incidence
  • Male
  • Metaplasia
  • Mice
  • Middle Aged
  • Polymorphism, Genetic
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / prevention & control

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Cytokines