Abstract
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenocarcinoma / epidemiology
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Adenocarcinoma / etiology*
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Adenocarcinoma / microbiology
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Adenocarcinoma / prevention & control
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Adolescent
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Adult
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Animals
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Anti-Bacterial Agents / therapeutic use
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Apoptosis
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Atrophy
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology
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Child
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Child, Preschool
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Cytokines / genetics
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Disease Progression
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Esophageal Neoplasms / epidemiology
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Esophageal Neoplasms / prevention & control
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Female
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Gastric Mucosa / microbiology
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Gastric Mucosa / pathology
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Gastritis / microbiology
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Gastroesophageal Reflux / epidemiology
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Gastrointestinal Neoplasms / epidemiology
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Gastrointestinal Neoplasms / etiology*
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Gastrointestinal Neoplasms / microbiology
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Gastrointestinal Neoplasms / prevention & control
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Genetic Predisposition to Disease
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Gerbillinae
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Helicobacter Infections / complications*
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Helicobacter Infections / drug therapy
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Helicobacter Infections / epidemiology
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Helicobacter pylori / isolation & purification
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Helicobacter pylori / pathogenicity*
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Helicobacter pylori / physiology
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Humans
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Incidence
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Male
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Metaplasia
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Mice
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Middle Aged
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Polymorphism, Genetic
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Randomized Controlled Trials as Topic
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Risk Factors
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Stomach Neoplasms / epidemiology
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Stomach Neoplasms / etiology
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Stomach Neoplasms / microbiology
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Stomach Neoplasms / prevention & control
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Cytokines