Hypoxia--a Key Regulatory Factor in Tumour Growth

Nat Rev Cancer. 2002 Jan;2(1):38-47. doi: 10.1038/nrc704.

Abstract

Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death. Cancer cells have adapted these pathways, allowing tumours to survive and even grow under hypoxic conditions, and tumour hypoxia is associated with poor prognosis and resistance to radiation therapy. Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics
  • Apoptosis
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Division
  • Cell Hypoxia*
  • Cell Survival
  • Cyclic AMP Response Element-Binding Protein / physiology
  • DNA Damage
  • DNA-Binding Proteins / physiology*
  • Dimerization
  • Embryonic and Fetal Development
  • Endothelial Growth Factors / physiology
  • Erythropoietin / therapeutic use
  • Forecasting
  • Gene Expression Regulation
  • Glycolysis
  • Humans
  • Hydrogen-Ion Concentration
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Lymphokines / physiology
  • Mice
  • NF-kappa B / physiology
  • Neoplasms / blood supply
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism
  • Nuclear Proteins / physiology*
  • Oxidation-Reduction
  • Oxidative Stress
  • Oxygen / metabolism
  • Prodrugs / pharmacokinetics
  • Proto-Oncogene Proteins / physiology
  • Receptor Protein-Tyrosine Kinases / physiology
  • Receptors, Aryl Hydrocarbon*
  • Signal Transduction
  • Trans-Activators / deficiency
  • Trans-Activators / genetics
  • Trans-Activators / physiology
  • Transcription Factors / deficiency
  • Transcription Factors / genetics
  • Transcription Factors / physiology
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factors
  • Xenograft Model Antitumor Assays

Substances

  • ARNT protein, human
  • Antineoplastic Agents
  • Arnt protein, mouse
  • Basic Helix-Loop-Helix Transcription Factors
  • Cyclic AMP Response Element-Binding Protein
  • DNA-Binding Proteins
  • Endothelial Growth Factors
  • HIF1A protein, human
  • Hif1a protein, mouse
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Lymphokines
  • NF-kappa B
  • Nuclear Proteins
  • Prodrugs
  • Proto-Oncogene Proteins
  • Receptors, Aryl Hydrocarbon
  • Trans-Activators
  • Transcription Factors
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Erythropoietin
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • endothelial PAS domain-containing protein 1
  • Receptor Protein-Tyrosine Kinases
  • Vascular Endothelial Growth Factor Receptor-1
  • Oxygen