Long-term Results in Patients With Onychomycosis Treated With Terbinafine or Itraconazole

Br J Dermatol. 2002 Feb;146(2):250-3. doi: 10.1046/j.1365-2133.2002.04639.x.

Abstract

Background: Previously, a double-blind, randomized, multicentre study (LION study) compared the efficacy of continuous terbinafine 250 mg daily for 3 or 4 months with itraconazole pulse therapy 400 mg daily for 3 or 4 months. At the end of the study at week 72 terbinafine proved to be more effective.

Objectives: To perform a 4-year follow-up of the Finnish participants in this study.

Methods: Patients were re-examined clinically and mycologically.

Results: Complete clinical and mycological cure with terbinafine for 4 months was 78% compared with 35% with terbinafine for 3 months, 24% with itraconazole for 4 months and 28% with itraconazole for 3 months.

Conclusions: These results suggest that the initial treatment for onychomycosis should be a 4-month continuous course of terbinafine.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antifungal Agents / therapeutic use*
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Foot Dermatoses / drug therapy
  • Foot Dermatoses / microbiology
  • Humans
  • Itraconazole / therapeutic use*
  • Male
  • Middle Aged
  • Naphthalenes / therapeutic use*
  • Onychomycosis / drug therapy*
  • Onychomycosis / microbiology
  • Terbinafine
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Naphthalenes
  • Itraconazole
  • Terbinafine