Syndecan-1 in B lymphoid malignancies

Ann Hematol. 2002 Mar;81(3):125-35. doi: 10.1007/s00277-002-0437-8. Epub 2002 Mar 1.


Syndecans are heparan sulfate-bearing proteoglycans that are found on the surface of most cells. Syndecan-1 is expressed predominantly on epithelia, but is also present on pre-B cells and plasma cells. The syndecans act to bind various effector molecules via their heparan sulfate chains, including both soluble and insoluble molecules within the extracellular milieu. These interactions promote cell adhesion to extracellular matrix and to adjacent cells. In addition, the syndecans can bind to and affect the biological activity of a number of heparin-binding growth factors. Thus, syndecan-1 can play a dramatic role in regulating cell behavior. In this review we discuss the expression of syndecan-1 on malignant B lymphoid cells as well as specific structure-function relationships of the molecule. Emphasis is placed on the important role that syndecan-1 has in regulating the growth of B lymphoid malignancies, particularly multiple myeloma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism*
  • B-Lymphocytes / pathology*
  • Humans
  • Lymphoma / metabolism*
  • Lymphoma / pathology*
  • Membrane Glycoproteins / metabolism*
  • Membrane Glycoproteins / physiology
  • Multiple Myeloma / metabolism*
  • Multiple Myeloma / pathology*
  • Proteoglycans / metabolism*
  • Proteoglycans / physiology
  • Syndecan-1
  • Syndecans


  • Membrane Glycoproteins
  • Proteoglycans
  • SDC1 protein, human
  • Syndecan-1
  • Syndecans