In this study, an erbium,chromium:YSGG (Er,Cr:YSGG) laser emitting at a wavelength of 2.78 microm was clinically applied to remove caries and prepare cavities, and the clinical outcome was evaluated. Effective clinical application of Er,Cr:YSGG laser had been expected from previous studies. This study included 44 patients (26 females, 18 males; aged 23-58) with a total of 50 cavity preparations by the Er,Cr:YSGG laser irradiation at 3-6 W with water spray. Patient acceptance and prognosis were evaluated. Most cases (94%) were prepared without anesthesia, and no pain was felt in 34 cases (68%). No adverse reaction was observed in any of the cases, and patient acceptance for this system was favorable. All cases had a good prognosis. In 45 cases (90%), overall clinical evaluation was satisfactory. From the present study, it can be concluded that the Er,Cr:YSGG laser system is an efficient, effective, and safe device for caries removal and cavity preparation.