Transforming growth factor-beta in T-cell biology

Nat Rev Immunol. 2002 Jan;2(1):46-53. doi: 10.1038/nri704.


Strict control of T-cell homeostasis is required to permit normal immune responses and prevent undesirable self-targeted responses. Transforming growth factor-beta (TGF-beta) has been shown to have an essential role in that regulation. Owing to its broad expression, and inhibitory effects on multiple cell types of the immune system, TGF-beta regulation is complex. Through advances in cell-specific targeting of TGF-beta signalling in vivo, the role of TGF-beta in T-cell regulation has become clearer. Recent in vitro studies provide a better understanding of how TGF-beta regulates T-cell homeostasis, through multiple mechanisms involving numerous cell types.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Apoptosis
  • Autoantigens
  • Autoimmunity
  • Cell Differentiation
  • Homeostasis
  • Humans
  • Lymphocyte Activation
  • Models, Immunological
  • Neoplasms / immunology
  • Signal Transduction
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • Transforming Growth Factor beta / immunology*


  • Autoantigens
  • Transforming Growth Factor beta