Central corneal thickness, radius of the corneal curvature and intraocular pressure in normal subjects using non-contact techniques: Reykjavik Eye Study

Acta Ophthalmol Scand. 2002 Feb;80(1):11-5. doi: 10.1034/j.1600-0420.2002.800103.x.


Purpose: To establish a population profile of central corneal thickness (CCT), radius of the corneal curvature (CC) and intraocular pressure (IOP) and the relationships between them using non-contact techniques.

Methods: We used a population-based random sample of 415 male and 510 female Caucasians aged 50 years and older. CCT and the radius of CC were measured with Scheimpflug anterior segment photography. IOP was measured with air-puff tonometry.

Results: The mean IOP of right eyes was 15.1 mmHg (SD 3.3) among men and 15.8 mmHg among women (SD 3.1), which is a statistically significant difference. The mean radius of CC for male right eyes was 7.78 (SD 0.60) and for females 7.62 (SD 0.58) which is also statistically significant. Mean CCT for male right eyes was 0.528 mm (SD 0.041) and for females 0.526 mm (SD 0.037), which is not a significant difference. Linear regression analysis shows no relationship between the radius of CC and IOP or between age and radius of CC. Linear regression analysis of the relationship between CCT and IOP suggests higher IOP measurements with thicker corneas. There was no significant correlation between age and CCT.

Conclusion: IOP was found to be independent of age and significantly higher in females than in males. Radius of CC was found to be age-independent and significantly steeper in females than in males. CCT appears to be independent of age and gender. Greater CCT is associated with higher mean IOP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Cornea / anatomy & histology*
  • Cornea / physiology*
  • Female
  • Humans
  • Iceland
  • Intraocular Pressure / physiology*
  • Male
  • Middle Aged
  • Random Allocation
  • Reference Values
  • Sex Factors
  • Tonometry, Ocular