Riboflavin deficiency in cystic fibrosis: three case reports

J Hum Nutr Diet. 2001 Oct;14(5):365-70. doi: 10.1046/j.1365-277x.2001.00306.x.


Three cases of clinical riboflavin deficiency are reported in children aged 2-10 years attending a regional Cystic Fibrosis clinic. Riboflavin deficiency presented as angular stomatitis in all three patients. Patients were confirmed to be riboflavin deficient by assaying the activity of erythrocyte glutathione reductase. Patients were not on routine supplements of water-soluble vitamins before presentation and were treated with riboflavin supplements as part of a water-soluble vitamin complex. At presentation, one patient had poor nutritional status, but two patients were adequately nourished, receiving overnight Gastrostomy feeds. Data on these two patients indicate an adequate dietary intake of riboflavin, suggesting a mechanism for increased requirements, inadequate absorption or utilization. Additional deficiencies of thiamin, pyridoxine and iron were also observed. This paper reports the occurrence of a vitamin deficiency not previously reported in the cystic fibrosis population.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child
  • Cystic Fibrosis / complications*
  • Dietary Supplements
  • Female
  • Glutathione Reductase / metabolism*
  • Humans
  • Infant
  • Male
  • Nutritional Requirements
  • Riboflavin Deficiency / diagnosis
  • Riboflavin Deficiency / etiology*
  • Riboflavin Deficiency / therapy
  • Stomatitis / diagnosis
  • Stomatitis / etiology
  • Stomatitis / therapy


  • Glutathione Reductase