Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum

J Nat Prod. 2002 Mar;65(3):299-305. doi: 10.1021/np010395f.

Abstract

Six new xanthones, cratoxyarborenones A-F (1-6), were isolated from the leaves, twigs, and/or stem bark of Cratoxylum sumatranum along with the known compound, vismione B (9), as active constituents by bioassay-directed fractionation using the KB human cancer cell line cytotoxicity assay. In addition, two novel anthraquinobenzophenones, cratoxyarborequinones A (7) and B (8), and two known compounds, 2,4,6-trihydroxybenzophenone 4-O-geranyl ether and delta-tocotrienol, were obtained as inactive constituents.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anthracenes / chemistry
  • Anthracenes / isolation & purification*
  • Anthracenes / pharmacology
  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification*
  • Anthraquinones / pharmacology
  • Benzophenones / chemistry
  • Benzophenones / isolation & purification*
  • Benzophenones / pharmacology
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Humans
  • Indonesia
  • KB Cells / drug effects
  • Leukemia P388
  • Mice
  • Mice, Inbred DBA
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Tumor Cells, Cultured / drug effects
  • Vitamin E / analogs & derivatives*
  • Vitamin E / chemistry
  • Vitamin E / isolation & purification
  • Vitamin E / pharmacology
  • Xanthenes / chemistry
  • Xanthenes / isolation & purification*
  • Xanthones*

Substances

  • 2,4,6-trihydroxybenzophenone 4-O-geranyl ether
  • Anthracenes
  • Anthraquinones
  • Benzophenones
  • Xanthenes
  • Xanthones
  • cratoxyarborequinone A
  • cratoxyarborequinone B
  • vismione B
  • Vitamin E
  • tocotrienol, delta
  • xanthone