Abstract
From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein, shamixanthone, and tajixanthone hydrate, were identified. The chemical structures of 1-4 were established by means of spectroscopic techniques and some chemical transformations. In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Benzyl Alcohols / chemistry
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Benzyl Alcohols / isolation & purification*
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Benzyl Alcohols / pharmacology
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Breast Neoplasms
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Caribbean Region
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Central Nervous System Neoplasms
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Colonic Neoplasms
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Cyclopentanes
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Drug Screening Assays, Antitumor
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Ergosterol
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Female
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Fungi / chemistry*
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Fungi / drug effects
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Humans
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Kidney Neoplasms
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Leukemia P388
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Lung Neoplasms
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Male
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Mice
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera
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Prostatic Neoplasms
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured / drug effects
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Xanthenes / chemistry
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Xanthenes / isolation & purification*
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Xanthenes / pharmacology
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Xanthones*
Substances
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Antibiotics, Antineoplastic
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Antifungal Agents
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Benzyl Alcohols
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Cyclopentanes
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Furans
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Xanthenes
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Xanthones
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dihydroterrein
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varioxirane
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varitriol
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varixanthone
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terrein
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xanthone
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Ergosterol