Long term behavior of lithographically prepared in vitro neuronal networks

Phys Rev Lett. 2002 Mar 18;88(11):118102. doi: 10.1103/PhysRevLett.88.118102. Epub 2002 Mar 4.


We measured the long term spontaneous electrical activity of neuronal networks with different sizes, grown on lithographically prepared substrates and recorded with multi-electrode-array technology. The time sequences of synchronized bursting events were used to characterize network dynamics. All networks exhibit scale-invariant Lévy distributions and long-range correlations. These observations suggest that different-size networks self-organize to adjust their activities over many time scales. As predictions of current models differ from our observations, this calls for revised models.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrodes
  • Models, Biological*
  • Nerve Net / physiology*
  • Neurons / physiology