A unified theory of gene expression

Cell. 2002 Feb 22;108(4):439-51. doi: 10.1016/s0092-8674(02)00655-4.


The human genome has been called "the blueprint for life." This master plan is realized through the process of gene expression. Recent progress has revealed that many of the steps in the pathway from gene sequence to active protein are connected, suggesting a unified theory of gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Chromatin / metabolism
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Genome, Human*
  • Histones / metabolism
  • Humans
  • Models, Genetic*
  • Nuclear Proteins / metabolism
  • Promoter Regions, Genetic
  • RNA Polymerase II / metabolism*
  • RNA Processing, Post-Transcriptional


  • Chromatin
  • DNA-Binding Proteins
  • Histones
  • Nuclear Proteins
  • RNA Polymerase II