Cooperation Between Complexes That Regulate Chromatin Structure and Transcription

Cell. 2002 Feb 22;108(4):475-87. doi: 10.1016/s0092-8674(02)00654-2.

Abstract

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we discuss how the activities of two major classes of chromatin-modifying complexes, ATP-dependent remodeling complexes and HAT or HDAC complexes, might be coordinated to create a DNA template that is accessible to the general transcription apparatus.

Publication types

  • Review

MeSH terms

  • Acetyltransferases / metabolism*
  • Adenosine Triphosphate / metabolism
  • Animals
  • Chromatin / chemistry
  • Chromatin / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Histone Acetyltransferases
  • Humans
  • Macromolecular Substances
  • Models, Biological
  • Nuclear Proteins / metabolism
  • Nucleosomes / metabolism
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / metabolism*
  • Transcription, Genetic / physiology*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Macromolecular Substances
  • Nuclear Proteins
  • Nucleosomes
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Adenosine Triphosphate
  • Acetyltransferases
  • Histone Acetyltransferases