Integrating mRNA processing with transcription

Cell. 2002 Feb 22;108(4):501-12. doi: 10.1016/s0092-8674(02)00617-7.


The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Histones / genetics
  • Histones / metabolism
  • Models, Genetic
  • RNA Polymerase II / metabolism*
  • RNA Processing, Post-Transcriptional / physiology*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Transcription, Genetic / physiology*


  • Histones
  • RNA, Messenger
  • RNA Polymerase II