Mitotic exit: delaying the end without FEAR

Curr Biol. 2002 Mar 19;12(6):R221-3. doi: 10.1016/s0960-9822(02)00756-x.


Activation of Cdc14 phosphatase, controlled by a signalling cascade known as the mitotic exit network, is the final switch that drives cells from mitosis into the next cell cycle. The recent discovery of a novel network that regulates early Cdc14 activation has revealed the unexpected existence of a two-step control of mitotic exit.

Publication types

  • Review

MeSH terms

  • Anaphase / physiology
  • Cell Cycle Proteins / metabolism*
  • Fungal Proteins
  • GTP-Binding Proteins / metabolism
  • Mitosis*
  • Nuclear Proteins
  • Protein Kinases / metabolism
  • Protein Tyrosine Phosphatases*
  • Protein-Serine-Threonine Kinases
  • Saccharomyces cerevisiae Proteins*
  • Signal Transduction


  • CDC14 protein, S cerevisiae
  • CDC15 protein
  • Cell Cycle Proteins
  • Fungal Proteins
  • Nuclear Proteins
  • SPO12 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • CDC5 protein, S cerevisiae
  • Protein Tyrosine Phosphatases
  • GTP-Binding Proteins