Aseptic meningitis associated with rofecoxib

Arch Intern Med. 2002 Mar 25;162(6):713-5. doi: 10.1001/archinte.162.6.713.


Rofecoxib is a nonsteroidal anti-inflammatory drug that is reported to act by selectively inhibiting cyclooxygenase-2. A review and analysis of reports sent to the Spontaneous Reporting System of the Food and Drug Administration, Rockville, Md, suggest that aseptic meningitis is associated with rofecoxib use. To our knowledge, there have been no published reports of aseptic meningitis occurring in association with rofecoxib use to date. We report 5 serious cases of aseptic meningitis associated with rofecoxib use.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis, Rheumatoid / drug therapy
  • Carpal Tunnel Syndrome / drug therapy
  • Female
  • Humans
  • Lactones / adverse effects*
  • Lactones / therapeutic use
  • Male
  • Meningitis, Aseptic / chemically induced*
  • Meningitis, Aseptic / diagnosis
  • Middle Aged
  • Neck Pain / drug therapy
  • Osteoarthritis / drug therapy
  • Pain, Postoperative / drug therapy
  • Sulfones


  • Anti-Inflammatory Agents, Non-Steroidal
  • Lactones
  • Sulfones
  • rofecoxib