Possible involvement of a muscarinic receptor in the anti-allodynic action of a 5-HT2 receptor agonist in rats with nerve ligation injury

Brain Res. 2002 Apr 5;932(1-2):124-8. doi: 10.1016/s0006-8993(02)02288-6.

Abstract

Intrathecal administration of 5-HT(2) receptor agonists produces an anti-allodynic effect in a rat model of neuropathic pain. Several non-serotonergic neurotransmitters have been implicated these anti-nociceptive effects. In the present study, intrathecal pre-treatment with the muscarinic receptor antagonist atropine (10 and 30 microg) and pirenzepine (10 microg) reversed the anti-allodynic effect of the 5-HT(2) receptor agonist alpha-methyl-5-hydroxytryptamine, unlike various other antagonists. Thus, muscarinic receptors may be involved in the anti-allodynic action of intrathecally injected 5-HT(2) receptor agonist.

MeSH terms

  • Analgesics / pharmacology
  • Animals
  • Injections, Spinal
  • Ligation
  • Male
  • Muscarinic Antagonists / pharmacology
  • Pain Measurement / drug effects
  • Rats
  • Rats, Wistar
  • Receptors, Muscarinic / physiology*
  • Receptors, Serotonin / physiology*
  • Serotonin / analogs & derivatives*
  • Serotonin / pharmacology
  • Serotonin Receptor Agonists / pharmacology
  • Spinal Nerves / drug effects
  • Spinal Nerves / injuries
  • Spinal Nerves / physiology*

Substances

  • Analgesics
  • Muscarinic Antagonists
  • Receptors, Muscarinic
  • Receptors, Serotonin
  • Serotonin Receptor Agonists
  • alpha-methylserotonin
  • Serotonin