VHS domain -- a longshoreman of vesicle lines

FEBS Lett. 2002 Feb 20;513(1):19-23. doi: 10.1016/s0014-5793(01)03287-2.


The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Endosomal Sorting Complexes Required for Transport
  • Molecular Sequence Data
  • Phosphoproteins / chemistry
  • Phosphoproteins / metabolism
  • Protein Conformation
  • Proteins / chemistry*
  • Proteins / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • trans-Golgi Network / metabolism


  • Endosomal Sorting Complexes Required for Transport
  • Phosphoproteins
  • Proteins
  • hepatocyte growth factor-regulated tyrosine kinase substrate