The FHA domain

FEBS Lett. 2002 Feb 20;513(1):58-66. doi: 10.1016/s0014-5793(01)03294-x.

Abstract

The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain-mediated phospho-dependent assembly of protein complexes is an ancient and widespread regulatory mechanism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Binding Sites
  • DNA Damage
  • DNA Repair
  • Enzymes / chemistry
  • Enzymes / metabolism
  • Epitopes / metabolism
  • Kinesin / chemistry
  • Kinesin / metabolism
  • Molecular Sequence Data
  • Phosphopeptides / chemistry*
  • Phosphopeptides / metabolism
  • Phosphoric Monoester Hydrolases / chemistry
  • Phosphoric Monoester Hydrolases / metabolism
  • Phosphothreonine / metabolism
  • Phosphotransferases / chemistry
  • Phosphotransferases / metabolism
  • Protein Conformation
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism

Substances

  • Bacterial Proteins
  • Enzymes
  • Epitopes
  • Phosphopeptides
  • RNA-Binding Proteins
  • Transcription Factors
  • Phosphothreonine
  • Phosphotransferases
  • Phosphoric Monoester Hydrolases
  • Kinesin