The phosphatidylinositol 3-phosphate-binding FYVE finger

FEBS Lett. 2002 Feb 20;513(1):77-84. doi: 10.1016/s0014-5793(01)03308-7.


The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Nematoda
  • Phosphatidylinositol 3-Kinases / chemistry
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphatidylinositol Phosphates / metabolism*
  • Protein Conformation
  • Protein Kinases / chemistry
  • Protein Kinases / metabolism
  • Protein Structure, Secondary
  • Saccharomyces cerevisiae / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Phosphatidylinositol Phosphates
  • phosphatidylinositol 3-phosphate
  • Protein Kinases
  • PIKFYVE protein, human