Normalization of nomenclature for peptide motifs as ligands of modular protein domains

FEBS Lett. 2002 Feb 20;513(1):141-4. doi: 10.1016/s0014-5793(01)03295-1.


We propose a normalization of symbols and terms used to describe, accurately and succinctly, the detailed interactions between amino acid residues of pairs of interacting proteins at protein:protein (or protein:peptide) interfaces. Our aim is to unify several diverse descriptions currently in use in order to facilitate communication in the rapidly progressing field of signaling by protein domains. In order for the nomenclature to be convenient and widely used, we also suggest a parallel set of symbols restricted to the ASCII format allowing accurate parsing of the nomenclature to a computer-readable form. This proposal will be reviewed in the future and will therefore be open for the inclusion of new rules, modifications and changes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Binding Sites
  • Ligands
  • Peptides / chemistry*
  • Peptides / classification
  • Protein Binding
  • Proteins / chemistry*
  • Proteins / metabolism
  • Terminology as Topic*
  • src Homology Domains


  • Ligands
  • Peptides
  • Proteins