Practical psychopharmacology in HIV-1 and acquired immunodeficiency syndrome

Psychiatr Clin North Am. 2002 Mar;25(1):149-75. doi: 10.1016/s0193-953x(03)00056-x.


HIV-1 infection poses a challenge for psychiatrists of the medically ill. Many factors concerning the care of HIV-1-infected patients need to be considered when prescribing psychotropics. These include careful diagnosis, taking into account medical disorders associated with HIV-1 that can present with psychiatric symptoms, as well as medications that HIV-1 patients may be taking that can cause a variety of neuropsychiatric side effects. Another important issue is the potential for drug-illness interactions. In general, HIV-1 patients seem to be more sensitive to the development of adverse drug reactions than do non-HIV-1 patients, especially as the illness progresses. It is also important to be cognizant of the complex multidrug regimens that many HIV-1 patients are on to avoid known drug-drug interactions and be on the alert for other potential interactions when using psychotropic medications.

Publication types

  • Review

MeSH terms

  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use
  • Drug Interactions
  • Drug Therapy, Combination
  • HIV Infections / drug therapy
  • HIV Infections / psychology*
  • HIV-1*
  • Humans
  • Mental Disorders / diagnosis
  • Mental Disorders / drug therapy*
  • Mental Disorders / psychology
  • Psychotropic Drugs / adverse effects
  • Psychotropic Drugs / therapeutic use*


  • Anti-HIV Agents
  • Psychotropic Drugs