Haematopoietic cell-fate decisions, chromatin regulation and ikaros

Nat Rev Immunol. 2002 Mar;2(3):162-74. doi: 10.1038/nri747.


The regulated production of several terminally differentiated cell types of the blood and immune systems (haematopoiesis) has been the focus of many studies on cell-fate determination. Chromatin and the control of its structure have been implicated in the regulation of cell-fate decisions and in the maintenance of the determined states. Here, I review advances in the field, emphasizing the potential role of chromatin in lineage commitment and differentiation. In this context, I discuss Ikaros, an essential regulator of lymphocyte development and an integral component of a functionally diverse chromatin remodelling network that operates from the early stages of haematopoiesis to the mature lymphocytes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Lineage
  • Chromatin / physiology*
  • DNA / metabolism
  • DNA-Binding Proteins*
  • Hematopoietic Stem Cells / physiology*
  • Histones / metabolism
  • Humans
  • Ikaros Transcription Factor
  • Transcription Factors / chemistry
  • Transcription Factors / physiology*


  • Chromatin
  • DNA-Binding Proteins
  • Histones
  • IKZF1 protein, human
  • Transcription Factors
  • Ikaros Transcription Factor
  • DNA