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Review
. 2002 Feb;18(1):103-20, vii.
doi: 10.1016/s0749-0690(03)00037-5.

The Aged Epidermal Permeability Barrier: Basis for Functional Abnormalities

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Review

The Aged Epidermal Permeability Barrier: Basis for Functional Abnormalities

Peter M Elias et al. Clin Geriatr Med. .

Abstract

Aged epidermis develops an abnormality in permeability barrier homeostasis, which is accentuated further in photoaged skin. The biochemical basis is a global reduction in stratum corneum lipids and profound abnormality in cholesterol synthesis. Various cytokine/growth factor signaling pathways are abnormal in aged skin, particularly in the interleukin-1 family. Barrier repair therapy can be effective in restoring normal function if a cholesterol-dominant mixture of the three key physiologic lipids, including ceramides and free fatty acids, is emphasized.

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