Abstract
Overexpression of the EvgA regulator of the two-component signal transduction system was previously found to modulate multidrug resistance of Escherichia coli by increasing efflux of drugs (K. Nishino and A. Yamaguchi, J. Bacteriol. 183:1455-1458, 2001). Here we present data showing that EvgA contributes to multidrug resistance through increased expression of the multidrug transporter yhiUV gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Outer Membrane Proteins / physiology
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Bacterial Proteins / physiology*
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Base Sequence
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Escherichia coli / drug effects
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Escherichia coli / genetics*
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Escherichia coli / metabolism
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Escherichia coli Proteins*
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Genes, Bacterial*
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Genes, MDR*
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Genes, Regulator
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Membrane Transport Proteins
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Molecular Sequence Data
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Phosphorylation
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Polymerase Chain Reaction
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Promoter Regions, Genetic
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Signal Transduction*
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Transcription Factors / physiology*
Substances
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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BvgA protein, Bacteria
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Escherichia coli Proteins
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EvgA protein, E coli
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Membrane Transport Proteins
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Transcription Factors
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tolC protein, E coli