EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli

J Bacteriol. 2002 Apr;184(8):2319-23. doi: 10.1128/JB.184.8.2319-2323.2002.

Abstract

Overexpression of the EvgA regulator of the two-component signal transduction system was previously found to modulate multidrug resistance of Escherichia coli by increasing efflux of drugs (K. Nishino and A. Yamaguchi, J. Bacteriol. 183:1455-1458, 2001). Here we present data showing that EvgA contributes to multidrug resistance through increased expression of the multidrug transporter yhiUV gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Outer Membrane Proteins / physiology
  • Bacterial Proteins / physiology*
  • Base Sequence
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli / metabolism
  • Escherichia coli Proteins*
  • Genes, Bacterial*
  • Genes, MDR*
  • Genes, Regulator
  • Membrane Transport Proteins
  • Molecular Sequence Data
  • Phosphorylation
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic
  • Signal Transduction*
  • Transcription Factors / physiology*

Substances

  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • BvgA protein, Bacteria
  • Escherichia coli Proteins
  • EvgA protein, E coli
  • Membrane Transport Proteins
  • Transcription Factors
  • tolC protein, E coli