The efficacy of acetic acid for glycogen repletion in rat skeletal muscle after exercise

Int J Sports Med. 2002 Apr;23(3):218-22. doi: 10.1055/s-2002-23172.


We examined the effect of acetic acid, the main component of vinegar, on glycogen repletion by using swimming-exercised rats. Rats were trained for 7 days by swimming. After an overnight fast, they were subjected to a 2-hr swimming exercise. Immediately afterward, they were given by gavage 2 ml of one of the following solutions: 30 % glucose only or 30 % glucose with 0.4 % acetic acid. Rats were sacrificed by decapitation before, immediately after exercise and 2 hours after the feeding. Exercise significantly decreased soleus and gastrocnemius glycogen content, and feeding significantly increased liver, soleus and gastrocnemius glycogen content. In soleus muscle, acetate feeding significantly increased glycogen content and the ratio of glycogen synthase in the I form (means +/- SEM: 4.04 +/- 0.41 mg/g-tissue and 47.0 +/- 0.7 %, respectively) in contrast to no acetate feeding (3.04 +/- 0.29 mg/g-tissue and 38.1 +/- 3.4 %, respectively). Thus, these findings suggest that the feeding of glucose with acetic acid can more speedily accelerate glycogen repletion in skeletal muscle than can glucose only.

MeSH terms

  • Acetic Acid / administration & dosage
  • Acetic Acid / pharmacology*
  • Animals
  • Glycogen / biosynthesis*
  • Male
  • Muscle, Skeletal / metabolism*
  • Physical Conditioning, Animal / physiology
  • Physical Endurance / physiology
  • Rats
  • Rats, Sprague-Dawley


  • Glycogen
  • Acetic Acid