Comparison of carbohydrate and milk-based beverages on muscle damage and glycogen following exercise

Int J Sport Nutr Exerc Metab. 2001 Dec;11(4):406-19. doi: 10.1123/ijsnem.11.4.406.

Abstract

This study examined effects of carbohydrate (CHO), milk-based carbohydrate-protein (CHO-PRO), or placebo (P) beverages on glycogen resynthesis, muscle damage, inflammation, and muscle function following eccentric resistance exercise. Untrained males performed a cycling exercise to reduce muscle glycogen 12 hours prior to performance of 100 eccentric quadriceps contractions at 120% of 1-RM (day 1) and drank CHO (n = 8), CHO-PRO (n = 9; 5 kcal/kg), or P (n = 9) immediately and 2 hours post-exercise. At 3 hours post-eccentric exercise, serum insulin was four times higher for CHO-PRO and CHO than P (p < .05). Serum creatine kinase (CK) increased for all groups in the 6 hours post-eccentric exercise (p < .01), with the increase tending to be lowest for CHO-PRO (p < .08) during this period. Glycogen was low post-exercise (33+/-3.7 mmol/kg ww), increased 225% at 24 hours, and tripled by 72 hours, with no group differences. The eccentric exercise increased muscle protein breakdown as indicated by urinary 3-methylhistidine and increased IL-6 with no effect of beverage. Quadriceps isokinetic peak torque was depressed similarly for all groups by 24% 24 hours post-exercise and remained 21% lower at 72 hours (p < .01). In summary, there were no influences of any post-exercise beverage on muscle glycogen replacement, inflammation, or muscle function.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Beverages*
  • Creatine Kinase / blood
  • Cytokines / blood
  • Dietary Carbohydrates / administration & dosage*
  • Dietary Carbohydrates / metabolism
  • Dietary Proteins / administration & dosage*
  • Dietary Proteins / metabolism
  • Exercise / physiology*
  • Glycogen / biosynthesis*
  • Glycogen / metabolism
  • Humans
  • Insulin / blood
  • Kinetics
  • Male
  • Methylhistidines / urine
  • Milk
  • Muscle, Skeletal / injuries
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / pathology

Substances

  • Cytokines
  • Dietary Carbohydrates
  • Dietary Proteins
  • Insulin
  • Methylhistidines
  • Glycogen
  • Creatine Kinase
  • 3-methylhistidine