The inhibitory effect of clindamycin on Lactobacillus in vitro

Infect Dis Obstet Gynecol. 2001;9(4):239-44. doi: 10.1155/S1064744901000394.


Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobocillus spp.

Methods: Concentrations of clindamycin ranging from 1.95-20,000 microg/ml were studied for their effect on the growth of six strains of Lactobacillus.

Results: Clindamycin concentrations between 1.95-31.25 microg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 microg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1,000 microg/ml.

Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Clindamycin / pharmacology*
  • Female
  • Humans
  • Lactobacillus / drug effects*
  • Lactobacillus / growth & development
  • Lactobacillus / metabolism
  • Microbial Sensitivity Tests


  • Anti-Bacterial Agents
  • Clindamycin