Multiplicity of mechanisms of serotonin receptor signal transduction

Pharmacol Ther. 2001 Nov-Dec;92(2-3):179-212. doi: 10.1016/s0163-7258(01)00169-3.


The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those subfamilies have been characterized by overlapping pharmacological properties, amino acid sequences, gene organization, and second messenger coupling pathways. Post-genomic modifications, such as alternative mRNA splicing or mRNA editing, creates at least 20 more G-protein-coupled 5-HT receptors, such that there are at least 30 distinct 5-HT receptors that signal through G-proteins. This review will focus on what is known about the signaling linkages of the G-protein-linked 5-HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenylyl Cyclases / biosynthesis
  • Adenylyl Cyclases / pharmacology
  • Cyclic AMP / metabolism
  • Humans
  • Ion Channels / physiology
  • Protein Kinases / biosynthesis
  • Protein Kinases / pharmacology
  • Receptors, Serotonin / physiology*
  • Signal Transduction / physiology*
  • Type C Phospholipases / biosynthesis
  • Type C Phospholipases / pharmacology


  • Ion Channels
  • Receptors, Serotonin
  • Cyclic AMP
  • Protein Kinases
  • Type C Phospholipases
  • Adenylyl Cyclases