Beneficial impact of genome projects on tuberculosis control

Infect Dis Clin North Am. 2002 Mar;16(1):145-61. doi: 10.1016/s0891-5520(03)00050-3.


The M. tuberculosis genome project is a landmark achievement in the history of TB research. The DNA sequence has provided valuable insights, along with a few surprises, into the complete genetic complement of M. tuberculosis. This information has been used to gain a better understanding of isoniazid-induced alteration in gene expression. It also has been used to construct a genealogy tree of different BCG strains, besides identifying genes that may be responsible for the human-specificity of M. tuberculosis. The impact of this project is far-reaching and in the next few years should yield innovative vaccines and therapeutic agents, besides aiding in the rapid and accurate diagnosis of TB.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Genome, Bacterial*
  • Humans
  • Mycobacterium tuberculosis / genetics*
  • Tuberculosis / microbiology*
  • Tuberculosis / therapy