Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma

Lancet. 2002 Mar 16;359(9310):943-5. doi: 10.1016/S0140-6736(02)07990-4.


Increased expression of survivin has been shown to be a negative predictor of survival in patients with soft-tissue sarcoma. We investigated 89 adults with soft-tissue sarcomas to ascertain the relation between co-expression of survivin and human telomerase reverse transcriptase (TERT) transcripts and prognosis. We quantified mRNA expression of survivin and TERT transcripts. Cox's proportional-hazards regression model showed co-expression of both genes to be a significant negative prognostic factor for patients with stage I to stage IV tumours (p=0 small middle dot0004; relative risk 20 small middle dot1, 95% CI 3 small middle dot8-106 small middle dot4) and for those at stage II and III (p=0 small middle dot0002; 42 small middle dot1, 6 small middle dot0-294 small middle dot9) compared with low expression of both genes. Co-expression of survivin and TERT transcripts identifies patients at high risk of tumour-related death.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chromosomal Proteins, Non-Histone / isolation & purification
  • Chromosomal Proteins, Non-Histone / metabolism*
  • DNA-Binding Proteins
  • Female
  • Humans
  • Inhibitor of Apoptosis Proteins
  • Male
  • Microtubule-Associated Proteins*
  • Neoplasm Proteins
  • Prognosis
  • Proportional Hazards Models
  • Sarcoma / metabolism*
  • Sarcoma / mortality
  • Sarcoma / pathology
  • Survival Rate
  • Survivin
  • Telomerase / isolation & purification
  • Telomerase / metabolism*
  • Time Factors


  • BIRC5 protein, human
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins
  • Neoplasm Proteins
  • Survivin
  • TERT protein, human
  • Telomerase