Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task

Psychopharmacology (Berl). 2002 Apr;160(4):371-80. doi: 10.1007/s00213-001-0994-x. Epub 2002 Feb 14.

Abstract

Rationale: Dopamine is important for enabling organisms to overcome work-related response costs. One way of investigating this function has been with concurrent choice procedures using food reinforcement. In the present study, rats were given a choice between pressing a lever for preferred Bioserve pellets, or approaching and consuming a less-preferred laboratory chow that was concurrently available. In previous work with this task, dopamine antagonists and accumbens dopamine depletions decreased lever pressing but increased chow consumption.

Objective: The present study assessed three drugs (two dopamine antagonists and one appetite suppressant) using the lever pressing/chow feeding task.

Results: Under baseline conditions, rats pressed the lever at high rates (1,300-1,500 responses) to obtain the preferred food, and little of the laboratory chow was eaten (1-2 g). Selective D1 and D2 antagonists (SKF 83566 and raclopride) reduced fixed ratio 5 lever pressing, but substantially increased chow consumption. In contrast, the serotonergic appetite suppressant fenfluramine reduced both lever pressing and chow consumption. With the dopamine antagonists, lever pressing and chow consumption were inversely correlated across treatments, while these two measures were unrelated in the fenfluramine experiment.

Conclusions: Dopamine antagonists and accumbens dopamine depletions do not simply reduce appetite. Rats with accumbens dopamine depletions, or rats treated with low doses of selective or non-selective dopamine antagonists, remain directed toward the acquisition and consumption of food. These results demonstrate that fundamental aspects of food reinforcement are left intact after treatment with low doses of dopamine antagonists.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / analogs & derivatives*
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology*
  • Animals
  • Appetite Depressants / pharmacology*
  • Choice Behavior / drug effects*
  • Choice Behavior / physiology
  • Dopamine Antagonists / pharmacology*
  • Eating / drug effects*
  • Eating / physiology
  • Fenfluramine / pharmacology*
  • Food Preferences / drug effects
  • Food Preferences / physiology
  • Male
  • Raclopride / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Reaction Time / drug effects*
  • Reaction Time / physiology
  • Reinforcement, Psychology
  • Serotonin Uptake Inhibitors / pharmacology

Substances

  • Appetite Depressants
  • Dopamine Antagonists
  • Serotonin Uptake Inhibitors
  • Fenfluramine
  • Raclopride
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • 1H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-