Serotonin 2a receptor T102C polymorphism and impaired impulse control

Am J Med Genet. 2002 Apr 8;114(3):336-9. doi: 10.1002/ajmg.10206.


Patients homozygous for the C allele of the T102C serotonin (5-HT) 2a receptor polymorphism have shown increased suicidal ideation or behavior in some reports, but not in others. We conducted a pilot investigation to determine whether this polymorphism might relate more specifically to a dimension of impaired impulse control, which may underlie only a portion of suicides. Rates of commission (impulsive) errors in a variant of the Continuous Performance Test (CPT) were compared across the genotypes of the T102C polymorphism in adults recruited from the community. The 102C/102C genotype was jointly associated with a greater incidence of past mood disorder or substance-use disorder, as well as significantly more commission errors compared to the 102T/102C and 102C/102C genotypes. These preliminary data suggest that the T102C 5-HT2a receptor polymorphism may be a marker for impaired behavior control-perhaps in the context of psychiatric disorder history.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analysis of Variance
  • DNA / genetics
  • Disruptive, Impulse Control, and Conduct Disorders / genetics*
  • Disruptive, Impulse Control, and Conduct Disorders / psychology
  • Female
  • Genotype
  • Humans
  • Impulsive Behavior / psychology
  • Male
  • Middle Aged
  • Mood Disorders / psychology
  • Polymorphism, Genetic
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin / genetics*
  • Substance-Related Disorders / psychology


  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin
  • DNA