Whole-pulmonary low-dose radiation therapy in agnogenic myeloid metaplasia with diffuse lung involvement

Am J Hematol. 2002 Apr;69(4):277-80. doi: 10.1002/ajh.10075.


Agnogenic myeloid metaplasia is a hematologic disorder accompanied by extramedullary hematopoiesis (EMH) affecting various organs. Lung involvement however is rare. We present the case of a 76-year-old woman with myelofibrosis, recurrent pleural effusions, pulmonary hypertension, and serious right cardiac failure. An open lung biopsy confirmed pulmonary EMH. She underwent low-dose (200 cGy) whole-lung radiotherapy in 4 fractions of 50 cGy each. Her clinical and hemodynamic parameters improved. We conclude that low-dose whole-lung radiation may be efficacious for the palliative treatment of pulmonary EMH.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Bone Marrow / pathology
  • Fatal Outcome
  • Female
  • Hematopoiesis, Extramedullary
  • Humans
  • Hypertension, Pulmonary
  • Lung / pathology
  • Lung Diseases / diagnosis*
  • Lung Diseases / pathology
  • Lung Diseases / radiotherapy*
  • Palliative Care
  • Pleural Effusion
  • Primary Myelofibrosis / pathology
  • Primary Myelofibrosis / physiopathology*