Comparison of serum concentrations of methotrexate after various routes of administration

Cancer. 1975 Nov;36(5):1619-24. doi: 10.1002/1097-0142(197511)36:5<1619::aid-cncr2820360514>;2-g.


Serum concentrations of methotrexate (MTX) were compared in 20 patients after administration of 15 mg/m2 MTX orally, intramuscularly, orally in divided doses, and/or intravenously. Higher and more sustained concentrations usually occurred after intramuscular administration of the drug. Approximately 50% of the patients had measurable serum concentrations 24 hours after a dose, except when the drug was given intravenously. In patients continued on MTX twice a week antimetabolic effects appeared sooner in persons with more sustained serum levels.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Female
  • Humans
  • Injections, Intramuscular
  • Injections, Intravenous
  • Male
  • Methotrexate / administration & dosage
  • Methotrexate / blood*
  • Methotrexate / therapeutic use
  • Middle Aged
  • Neoplasms / drug therapy
  • Time Factors


  • Methotrexate