Transient neonatal hypoglycemia--long-term effects on neurodevelopmental outcome

J Pediatr Endocrinol Metab. 2002 Mar;15(3):319-24. doi: 10.1515/jpem.2002.15.3.319.


Objective: To investigate the frequency, etiology and consequences of neonatal hypoglycemia.

Study design: Ninety-four infants admitted to Gazi University Hospital neonatal intensive care unit for hypoglycemia (blood glucose <2.2 mmol/l 140 mg/dl]) over the past 5 years were identified and investigated with regard to cause, duration of treatment and neurological outcome.

Results: The frequency of neonatal hypoglycemia in our unit was 94/1,023 (9.18%). Twelve infants with hypoglycemia were small for gestational age (SGA), 55 were appropriate for gestational age (AGA), and 27 were large for gestational age (LGA). The cause of the hypoglycemia was not identified in 53 infants. SGA infants required the longest duration of i.v. glucose infusion. Forty-eight patients received psychometric evaluation, one patient showed a language deficit and two patients showed motor deficits.

Conclusion: Neonatal hypoglycemia is a dangerous condition for its acute and chronic complications, and may be observed in infants with no clear risk factors. However, if acted upon early, these complications are preventable with mostly very simple measures.

MeSH terms

  • Blood Glucose / metabolism
  • Child Development / physiology*
  • Child, Preschool
  • Diabetes, Gestational / blood
  • Female
  • Follow-Up Studies
  • Humans
  • Hypoglycemia / epidemiology
  • Hypoglycemia / etiology
  • Hypoglycemia / physiopathology*
  • Infant
  • Infant, Newborn
  • Infant, Newborn, Diseases / epidemiology
  • Infant, Newborn, Diseases / etiology
  • Infant, Newborn, Diseases / physiopathology*
  • Infant, Premature / physiology
  • Infant, Small for Gestational Age / physiology
  • Male
  • Pregnancy
  • Psychometrics
  • Risk Factors


  • Blood Glucose