Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Mar;93(3):264-70. doi: 10.1067/moe.2002.120522.


Objective: We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions.

Study design: Over a 48-week period, we evaluated the evolution of pain, ulcerations, atrophy, and interference of the disease in the patient's daily life, classifying the response as complete (100% remission/recovery), excellent (75%), good (50%), poor (<50%), or failed.

Results: The pain and ulceration totally disappeared in 93.3% of cases and 90% reported a full recovery in their daily life activities. Atrophy response was complete in 28.5%, excellent in 60.7%, and good in 3.5%. Two patients showed no response to the treatment. Five patients suffered mild adverse effects (moon face and hirsutism) between week 4 and week 6 of treatment, which were speedily reversed by reducing the frequency of mouthwash.

Conclusions: Clobetasol mouthwash is a safe and efficacious option for the treatment of severe oral erosive lesions.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Anti-Inflammatory Agents / administration & dosage*
  • Clobetasol / administration & dosage*
  • Drug Administration Schedule
  • Female
  • Glucocorticoids
  • Humans
  • Lichen Planus, Oral / drug therapy*
  • Male
  • Middle Aged
  • Mouth Mucosa / pathology
  • Mouthwashes / administration & dosage*
  • Pemphigoid, Benign Mucous Membrane / drug therapy*
  • Stomatitis, Aphthous / drug therapy*
  • Treatment Outcome


  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Mouthwashes
  • Clobetasol