[A case of chronic hypersensitivity pneumonia with elevation of serum SP-D and KL-6]

Nihon Kokyuki Gakkai Zasshi. 2002 Jan;40(1):66-70.
[Article in Japanese]


A 73-year-old woman suffering from dyspnea on effort and chronic cough was admitted to our hospital. Chest computed tomography disclosed ground-glass opacities, irregular linear opacities and honeycombing distributed predominantly in the subpleural area. The serum levels of SP-D and KL-6 rose to 889 ng/ml, 1,755 U/ml, respectively. These findings indicated idiopathic pulmonary fibrosis. However, the number of lymphocytes and the CD4/CD8 ratio in the BAL fluid were elevated. Transbronchial lung biopsy specimens demonstrated alveolitis with granuloma formation. The evidence that she had lived in a house with a heavy fungal growth and that tests of precipitation in response to Penicillium corylophilum were positive confirmations of a diagnosis of chronic hypersensitivity pneumonia.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Alveolitis, Extrinsic Allergic / blood
  • Alveolitis, Extrinsic Allergic / microbiology*
  • Antigens
  • Antigens, Neoplasm
  • Chronic Disease
  • Female
  • Glycoproteins / blood*
  • Humans
  • Lung Diseases, Fungal / blood*
  • Mucin-1
  • Mucins
  • Mycoses / blood*
  • Penicillium*
  • Pulmonary Surfactant-Associated Protein D
  • Pulmonary Surfactants / blood*


  • Antigens
  • Antigens, Neoplasm
  • Glycoproteins
  • MUC1 protein, human
  • Mucin-1
  • Mucins
  • Pulmonary Surfactant-Associated Protein D
  • Pulmonary Surfactants