Reduction in the incidence of alveolar osteitis in patients treated with the SaliCept patch, containing Acemannan hydrogel

J Oral Maxillofac Surg. 2002 Apr;60(4):374-9; discussion 379. doi: 10.1053/joms.2002.31222.


Purpose: In the present study, we compared the incidence of alveolar osteitis (AO) in patients treated with either clindamycin-soaked Gelfoam (Pharmacia and Upjohn Co, Kalamazoo, MI) or SaliCept Patches (Carrington Laboratories, Inc, Irving, TX). The SaliCept Patch is a freeze-dried pledget that contains Acemannan Hydrogel (Carrington Laboratories) obtained from the clear inner gel of Aloe vera L.

Patients and methods: A retrospective evaluation was performed of the records of 587 patients (1,031 sockets) whose extraction sites had been treated with clindamycin-soaked Gelfoam. A prospective trial was conducted in which 607 patients (1,064 sockets) had 2 SaliCept Patches placed immediately after extraction. The same surgeon treated all patients.

Results: Analysis restricted to mandibular third molar sites showed that 78 of 975 sites (8.0%) in the Gelfoam group developed AO, whereas only 11 of 958 sites (1.1%) in the SaliCept group developed AO (P <.0001). Further analysis of all extraction sites revealed that the incidence of AO in the Gelfoam group was 7.6% compared with 1.1% in the SaliCept-treated group (P <.0001).

Conclusions: The study results suggest that the SaliCept Patch significantly reduces the incidence of AO compared with clindamycin-soaked Gelfoam.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aloe
  • Anti-Bacterial Agents / therapeutic use*
  • Child
  • Clindamycin / therapeutic use*
  • Dry Socket / etiology
  • Dry Socket / prevention & control*
  • Female
  • Gelatin Sponge, Absorbable / therapeutic use*
  • Hemostatics / therapeutic use*
  • Humans
  • Male
  • Mannans / therapeutic use*
  • Middle Aged
  • Phytotherapy
  • Plant Extracts / therapeutic use
  • Retrospective Studies
  • Tooth Extraction / adverse effects
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Hemostatics
  • Mannans
  • Plant Extracts
  • Clindamycin
  • acemannan