[Intensity of lipid peroxidation and antioxidant enzyme activity in arterial and venous walls during hypervitaminosis D]

Fiziol Zh (1994). 2002;48(1):87-90.
[Article in Ukrainian]


The intensity of the lipid peroxydation (LPO) and the antioxidant enzyme activity (superoxide dismutase, glutathione peroxydase and catalase) on injecting vitamin D in high doses (10,000 U/kg) was examined in the arterial and venous walls of rabbits. The increase in the amount of the intermediate and final LPO products has been found in the vessels of all types. The lowest intensity of LPO was noted in the vena cava. The decrease in the antioxidant activity has been revealed. But vena cava inferior was the exception because the activity of all studied antioxidant enzymes grew in its wall. This increase is likely to be one of the reasons for vena resistance to the action of damaging factors.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Arteries / enzymology*
  • Catalase / metabolism
  • Glutathione Peroxidase / metabolism
  • Lipid Peroxidation / drug effects*
  • Male
  • Metabolic Diseases / etiology
  • Metabolic Diseases / metabolism*
  • Rabbits
  • Superoxide Dismutase / metabolism
  • Venae Cavae / enzymology*
  • Vitamin D / administration & dosage*


  • Antioxidants
  • Vitamin D
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase