Gamma camera technique was used to assess the effectiveness of various exsanguination methods in 12 healthy male volunteers given an autologous injection of 99mTc-labeled erythrocytes. The methods used included elevation alone, Esmarch bandage, gauze bandage, and the Pomidor roll-cuff. The median times spent on use of these methods were: Esmarch 85 sec, gauze 104 sec, and Pomidor roll-cuff 18 sec. The various exsanguination methods caused a median percentage reduction in regional blood volume of the lower limbs: elevation 1/2 minute 45%, 1 minute 45%, 2 minutes 42%, 4 minutes 44%, 6 minutes 43%, 10 minutes 44%, Esmarch bandage 64%, gauze bandage 62%, and Pomidor roll-cuff 61%. No statistically significant differences were found between the elevation procedures. The external methods were more effective than elevation alone (p < 0.001).