Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling

Trends Immunol. 2002 Feb;23(2):96-101. doi: 10.1016/s1471-4906(01)02118-4.


The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon gamma (IFN-gamma). However, recent studies have shown that the IFN-gamma receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / immunology*
  • Fibroblasts
  • Gene Expression Regulation
  • Humans
  • Interferon-gamma / immunology*
  • Macrophages / immunology
  • Oligonucleotide Array Sequence Analysis
  • STAT1 Transcription Factor
  • Signal Transduction / immunology*
  • Trans-Activators / immunology*


  • DNA-Binding Proteins
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Trans-Activators
  • Interferon-gamma