A New Integron Carrying VIM-2 Metallo-Beta-Lactamase Gene Cassette in a Serratia Marcescens Isolate

Diagn Microbiol Infect Dis. 2002 Mar;42(3):217-9. doi: 10.1016/s0732-8893(01)00352-2.

Abstract

Serratia marcescens is an important nosocomial pathogen which is often resistant to multiple antimicrobial agents. An imipenem-resistant S. marcescens isolate from a urine specimen was found to carry a bla(VIM-2) gene cassette on a class 1 integron. This finding indicates that bla(VIM-2) is presently spreading even to Serratia spp. in Korea, which could compromise the usefulness of carbapenem in the treatment of multi-resistant Gram-negative bacilli infections. Clinical laboratory should be able to detect the VIM-2-producing isolates with even low carbapenem MIC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Korea
  • Microbial Sensitivity Tests
  • Mutagenesis, Insertional
  • Polymerase Chain Reaction
  • Recombination, Genetic / genetics*
  • Serratia marcescens / drug effects
  • Serratia marcescens / enzymology*
  • Serratia marcescens / genetics*
  • Serratia marcescens / isolation & purification
  • beta-Lactamases / genetics*
  • beta-Lactams

Substances

  • Anti-Bacterial Agents
  • beta-Lactams
  • VIM-1 metallo-beta-lactamase
  • beta-Lactamases