The pathology of hibernating myocardium

Nucl Med Commun. 2002 Apr;23(4):303-9. doi: 10.1097/00006231-200204000-00003.

Abstract

Myocardial hibernation represents a protective mechanism of muscle preservation in the setting of atherosclerotic coronary artery disease. Long-standing myocardial hypoperfusion leads to diminished myocardial contractility that reverses with improved blood flow after revascularization. The morphologic changes in both animal models and humans are described.

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Arteriosclerosis / complications*
  • Arteriosclerosis / pathology*
  • Arteriosclerosis / physiopathology
  • Disease Models, Animal
  • Humans
  • Ischemic Preconditioning, Myocardial
  • Myocardial Stunning / pathology*
  • Myocardial Stunning / physiopathology
  • Myocardium / pathology*
  • Ventricular Dysfunction, Left / etiology
  • Ventricular Dysfunction, Left / pathology
  • Ventricular Dysfunction, Left / physiopathology