Near the edge of a chromosome's "black hole"

Trends Genet. 2002 Apr;18(4):165-7. doi: 10.1016/s0168-9525(01)02622-1.


The inability of current technology to determine contiguous sequence for highly repetitive regions means that centromeres fall within multi-megabase gaps, analogous to black holes from which no information escapes. However, high-resolution mapping of a human X-centromere border reveals a remarkable structure, including a gradient of alpha-satellite divergence up to the edge of the youngest and most homogeneous repeats.

Publication types

  • News

MeSH terms

  • Centromere*
  • DNA Transposable Elements
  • DNA, Satellite / genetics
  • Euchromatin / genetics
  • Evolution, Molecular
  • Heterochromatin
  • Humans
  • Repetitive Sequences, Nucleic Acid
  • Sequence Analysis, DNA
  • X Chromosome*


  • DNA Transposable Elements
  • DNA, Satellite
  • Euchromatin
  • Heterochromatin